The International Genetically Engineered Machine (iGEM) Foundation is an independent, non-profit organization dedicated to education and competition, the advancement of synthetic biology, and the development of an open community and collaboration. Our team is participating in the iGEM competition wich is an international team competition made up of undergraduate and overgraduate students interested in the field of synthetic biology.
We are team iGEM and we will be participating in the iGEM synthetic biology competition in Boston later this year. Our aim is to contribute to a solution for one of the biggest threats to global health: antibiotic resistance. Misuse of antibiotics is one of the key accelerators of this process. Our solution lies in an improvement of diagnostics of infections to decrease and/or prevent the misuse. Bacteriophages can bind very selectively to bacteria, insert their genome, replicate and consequently lyse the bacteria. Only when this selective process occurs, the phage DNA is released and can then be bound by BRET molecular beacon technology. A point-of-care diagnostic method could be based on this, requiring only a (smartphone) camera to detect the change in wavelength of emitted light!